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Two children and an adult have died in a horrific truck collision in regional Victoria.

The truck collided with a car at the intersection of Eurambeen-Streatham and Mount William roads in Stoneleigh, west of Ballarat, about 9.30am on Tuesday.

Police say the car appears to have rolled and been crushed.

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An adult and two children died at the scene.

Another adult, who was trapped inside the car, suffered life-threatening injuries and will be airlifted to hospital.

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Two children, adult killed in collision

Two children and an adult have died in a horrific truck collision in regional Victoria.

The truck collided with a car at the intersection of Eurambeen-Streatham and Mount William roads in Stoneleigh, west of Ballarat, about 9.30am on Tuesday.

One person has died and another taken to hospital in a two-car crash in regional Victoria.

The two cars collided on the Glenelg Highway near Woorndoo-Streatham Road, far west of Melbourne, about 10am Sunday.

The female driver and sole occupant of one of the cars died at the scene.

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The male driver of the other car was taken to hospital with non-life-threatening injuries.

Both are yet to be formally identified.

The cause of the crash is under investigation.